The NUPR1 inhibitor ZZW-115 could block stress granule (SG) formation, induce apoptosis, and reduce pancreatic intraepithelial neoplasia development in KrasG12D-driven tumors, highlighting its potential as a therapeutic strategy for pancreatic cancer [38, 39, 44] and other cancers [45, 46]. The gene discussed is NUPR1; the disease is cancer.