SPP1 and cancer: Corroborating these findings, GC BLOW TCGA-SARC samples exhibited significantly higher CIBERSORT fraction of M2 macrophages and increased SPP1 expression, paralleled by reduced fraction of M1 TAMs and decreased expression of TIMD4 (better known as TIM4) and FOLR2 (Fig. 5B and S4A), whose expression by TAMs has been linked to TLS formation in different cancer settings [52–54].