At odds, we observed no significant differences in CD163+ cell accumulation in the whole TME among STS specimens divided based on TLS presence or CD20+ B cell accumulation, while a higher accumulation of CD163+ macrophages was observed in pleomorphic sarcomas (Figure S4B), even if they showed a higher TLS incidence and density compared to other histotypes (Fig. 1G). Here, CD163 is linked to Tumor Lysis Syndrome.