This self-therapeutic NP inhibits p38α mitogen-activated proteinkinase (MAPK) phosphorylation and pyruvate dehydrogenase kinase 1(PDK1) activity in the HD brain, upregulates the oxidative phosphorylationpathway (downstream of PDK1), and suppresses pyroptosis-induced celldeath (downstream of both kinases). This evidence concerns the gene PDK1 and Huntington disease.