Further,neuronal loss (a hallmark of human HD) in R6/2 HD mice is not as pronouncedas in HD patients., Therefore, exploration of efficacyin other disease models will improve the translatability of gold NP. Knock-in mouse models that express endogenousfull-length HTT protein with polyQ expansion, such as HdhQ150 and CAG140 KI, willallow for full length HTT protein deaggregation studies, longer-termefficacy and toxicity evaluation up to 24 months, and a more relevant studies for neuron loss. The gene discussed is HTT; the disease is Huntington disease.