IFNG and inflammation: EEC-specific MHCII deficiency resulted in exacerbated eosinophilic inflammation in a model of food antigen-dependent EoE.<h4>Conclusion</h4>We find a novel immunoregulatory role for IFNγ-dependent EEC-MHCII in the context of oesophageal food allergy.<h4>Clinical relevance</h4>Our results expand our understanding of oesophageal immune physiology and identify EEC-MHCII as mediating an anti-inflammatory axis that could be leveraged therapeutically.