Evans diagnostic criteria16 defined cachexia based on the presence of a 5 % weight loss in 12-months or less or BMI < 20 kg/m2 plus three out of the following five criteria: decreased muscle strength, fatigue, anorexia, low fat-free mass index, or abnormal biochemistry (increased C-reactive protein > 5.0 mg/L; low hemoglobin < 12 g/dL, and low serum albumin < 3.2 g/dL).16 This evidence concerns the gene CRP and Cachexia.