Furthermore, the predictive utility of single biomarkers is undermined by the dynamic alteration of the tumor microenvironment following therapeutic interventions (eg, chemotherapy or radiotherapy), as well as inconsistencies in detection methodologies and threshold definitions—such as the varying PD-L1 scoring systems (tumor proportion score, combined positive score, immune cell score, and H-score) and platform-dependent criteria for MSI and TMB. Here, CD274 is linked to neoplasm.