Key outcomes included serum testosterone levels, oxidative stress markers, inflammatory mediators, Bax/Bcl-2 expression, histopathological evaluations, and morphometric analyses.<h4>Results</h4>NG treatment attenuated CIS-induced oxidative stress by normalizing total oxidant status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI) levels while reducing pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and NF-κB activation. Here, TNF is linked to in situ carcinoma.