Time-dependent covariate Cox models compared incidence of cognitive decline and dementia across time-dependent FI groups, adjusted for demographics, <i>APOE</i> ε4 status, presence of neuropsychiatric symptoms, CDR sum of boxes, and informant characteristics (age, sex, relationship, cohabitation status).ResultsThe CN sample comprised 164 Persistent-FI (age = 75.7 ± 12.2; 59.1% female), 522 Transient-FI (age = 73.7 ± 9.5; 62.8% female), and 11,107 No-FI participants (age = 70.9 ± 8.9; 66.0% female). Here, APOE is linked to Mental deterioration.