DNMT1 and neoplasm: Because covalent trapping of DNMT1 on DNA has been shown to induce DNMT proteasomal degradation [20, 21], we assessed whether oral FdCyd-THU therapy yielded changes in tumor DNMT1 levels via IHC analysis of baseline (pre-dose) and on-treatment (Cycle 1 Week 3; C1W3) biopsy specimens.