PARP1 and retinitis pigmentosa 1: As in all autosomal‐dominant forms of RP, the I255del mutation is expected to lead to misfolding and aggregation of irregular rhodopsin protein in the endoplasmic reticulum (ER), and the ensuing unfolded protein response (UPR) may consume large amounts of ATP (Cao, Dahlen, et al. 2024; Cao, Zhu, et al. 2024) that would not be correctable by PARP inhibition.