STAT1 gain-of-function (STAT1GOF) is an immune disorder characterizedby an increased phosphorylation of STAT1 following interferon stimulation,leading to a broad clinical presentation, including life-threateninginvasive infections. The current standardof care includes antifungals and anti-inflammatory drugs, as wellas experimental treatments such as hematopoietic stem cell transportationand JAK inhibition. Pharmacological inhibitionof STAT1 is a potential alternative therapeutic approach for treatingSTAT1 GOF. The gene discussed is STAT1; the disease is infection.