Another investigation was conducted to design an innovative Angiopep-2 decorated PEG-block-poly-(2,2,3,3-tetrafluoropropyl methacrylate) (Ang-PEG-b-PFPMA) polymer delivery system that achieves simultaneous codelivery of temozolomide (TMZ) and siRNA against retinoblastoma binding protein 4 (RBBP4) for enhancing therapeutic efficacy in glioblastoma treatment. The gene discussed is RBBP4; the disease is glioblastoma.