In this work, GOx and symmetry-linked amidobenzimidazole (DiABZI), an agonist of stimulator of interferon genes (STING), were coloaded into ferrocene-containing polymersomes (PEG-b-P(FcMA-co-PEMA) nanoreactors) to improve STING activation and combine chemodynamics and immunotherapy in 4T1 tumor-bearing BALB/c mice. Here, STING1 is linked to neoplasm.