Following a single intravenous injection of a modest dose of DOX and HPPH, in vivo data showed that the all-in-one polymersomal nanoformulation enhanced mature dendritic cells in tumor-draining lymph nodes and CD8+ T lymphocytes in tumor tissues to suppress primary and distant MC38 tumor growth in C57BL/6 mice (Yang et al. 2019). Here, CD8A is linked to neoplasm.