STING1 and neoplasm: In a previous study, ADU-S100 encapsulated in reduction-responsive biodegradable PEG-P(TMC-DTC) polymersomes significantly improved the cytosolic delivery and tumor retention of ADU-S100, enhancing STING pathway activation and antitumor immunotherapy in malignant B16F10 melanoma-bearing C57BL/6J mice.