When all participants (regardless of AMD) were analyzed together, the serum level of TSP-1 in aspirin users had a non-significant trend toward lower values compared with that in non-aspirin users (p = 0.077, t = 1.433, df = 194.9, unpaired t-test with Welch’s correction, Figure 6B). This evidence concerns the gene THBS1 and age-related macular degeneration.