Notably, alleles associated with higher GNG4 expression in the eQTL study were tightly linked to the reported RA risk allele (maximum R2 = 0.94, P < 2.2e-16), suggesting that they likely tag a shared haplotype and that elevated GNG4 expression may be one mechanism through which this haplotype increases RA susceptibility. This evidence concerns the gene GNG4 and rheumatoid arthritis.