Given the widely distributed projections of serotonergic neurons in the brain - influencing a broad range of physiological and behavioral functions in both health and disease - and the predilection for glioma formation within and spread to the brainstem where serotonergic neuronal soma reside, we hypothesized a potential role for 5HT neurons in glioma pathophysiology. The gene discussed is HTR5A; the disease is central nervous system cancer.