IFNB1 and viral infectious disease: Interestingly, RNA Polymerase II (Pol II) is recruited at the promoter region of the IFN-β gene around 4 hrs after virus infection while mRNA of IFN-β was detected 6 hrs after virus infection (Agalioti, Lomvardas et al. 2000, Lomvardas and Thanos 2002).