Detailed characterization showed that NF-κB is first recruited less than 2 hrs after virus infection, followed by IRF-1 (2– 3 hrs after infection), p300/CBP (2–3 hrs), ATF2 (3–4 hrs) (Agalioti, Lomvardas et al. 2000, Lomvardas and Thanos 2002). This evidence concerns the gene EP300 and viral infectious disease.