IFNB1 and viral infectious disease: Interestingly, after deep characterization of the underlying mechanism of the function of the enhanceosome, it was found that the +1 nucleosome located from transcription start site of IFN-β gene was gone though the authors interpreted that the +1 nucleosome was sliding downstream after virus infection via chromatin remodelers such as SWI/SNF family and proposed that the enhanceosome is required to expose the promoter region for Pol II to bind (Lomvardas and Thanos 2001).