To date, causative genetic mutations identified in CHD/HTX patients often involve genes related to L-R asymmetric development (e.g., NODAL (Dardas et al., 2024), ZIC3 (Ware et al., 2004)) and ciliary assembly and function (e.g., DNAH11 (Liu et al., 2019), DNAH5 (Bolkier et al., 2022), DNAI1 (Kennedy et al., 2007)). This evidence concerns the gene ZIC3 and coronary artery disorder.