RAB7B and cirrhosis of liver: HSCs play a crucial rolein liver cirrhosis, differentiating into myofibroblasts and producingvast amounts of extracellular matrix, driving fibrosis formation.Thus, Pharmacological targeting of HSC activation remains a cornerstoneof antifibrotic therapy development. Zhoureported that IGF2BP2 was elevated in activated HSCs and silencingIGF2BP2 could inhibit HSCs activation and liver fibrosis. In this study, RAB7B was found to be significantlyupregulated in 10% serum and TGF-β induced environments, andits expression in the liver of cirrhotic mice was notably higher comparedto controls.