Following this MTDLapproach, a series of gramine-based neuroprotective drugs (7-azaindolederivatives) showing the ability to modulate the hyperphosphorylationof Tau protein were developed in the past decades as promising neuroprotectivedrugs.−,  Oral administration is a convenient route for theadministration of drugs to AD patients, but it would be necessaryto formulate a drug with prolonged drug release since AD is a chronicdisease. Here, MAPT is linked to Alzheimer disease.