As previously reported, retinoids can suppressantioxidant defenses and increase oxidative damage by downregulatingthe Keap1/Nrf2/ARE axis. Together, theseresults suggest that the nanosystem not only downregulates pro-inflammatorymediators but also modulates redox homeostasis, enhancing tumor susceptibilityto oxaliplatin. Here, KEAP1 is linked to neoplasm.