KLRC2 and ankylosing spondylitis: This shift in NK cell populations suggests a potential role in immune dysregulation and chronic inflammation in axSpA.82 Moreover, Tang et al.83 demonstrated that killer cell lectin-like receptor C2 (NKG2C+) CD8+ T cells, an aging-associated subset, exhibit enhanced cytotoxicity in ankylosing spondylitis, driven by HLA-B27-induced activation of the PI3K-Akt pathway.