Similarly, a study with 48 newly diagnosed patients with T2DM, all of whom received a 2-week course of SIIT, reported the following outcomes at the 1-year follow-up after treatment cessation: a notable decline in the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), a significant increase in the Homeostatic Model Assessment for β-cell function (HOMA-β), and improvement in the acute insulin response (AIRins). This evidence concerns the gene INS and type 2 diabetes mellitus.