Univariate Cox regression manifested that 24 genes within the HH pathway were associated with PC prognosis, with 10 genes (WNT9B, WNT2B, WNT10B, WNT4, WNT1, PTCH1, PRKACA, CSNK1D, BMP6, and BMP5) associated with a better prognosis and 14 genes (WNT7B, WNT7A, WNT5A, WNT2, WNT10A, SUFU, RAB23, GSK3B, GLI2, GAS1, CSNK1E, CSNK1A1, BMP8A, and BMP4) associated with a poorer prognosis (Figure 1c). The gene discussed is CSNK1A1; the disease is pachyonychia congenita.