PUF60 and microcephaly: Additional spliceosomal components linked to SyOFC include small nuclear ribonucleoprotein polypeptide E (SNRPE; associated with mandibulofacial dysostosis with microcephaly, MIM: 618733), small nuclear ribonucleoprotein polypeptide B (SNRPB; cerebro–costo–mandibular syndrome, MIM: 117650), Poly(U) Binding Splicing Factor 60 (PUF60; Verheij syndrome, MIM: 613976), and zinc finger CCCH‐Type, RNA binding motif and serine/arginine rich 2 (ZRSR2; variants reported in syndromic presentations with craniofacial features) [11, 12].