Mechanistically, these critical receptors mediate NK cell activation through distinct ligand interactions: NKG2D (a C‐type lectin‐like receptor) recognizes major histocompatibility complex class I‐related molecules expressed on tumor cells, while NCRs (NKp30 and NKp46) bind to immunoreceptor tyrosine‐based activation motif (ITAM)‐bearing ligands [194]. The gene discussed is KLRK1; the disease is neoplasm.