Concurrently, a cluster of chemokines (e.g., chemokine ligand 22 [CCL22]; and C‐X‐C motif chemokine ligand 12 [CXCL12]) are secreted to promote recruitment and infiltration of immunosuppressive cell populations, creating a permissive environment for tumor proliferation and metastatic dissemination [109]. Here, CXCL12 is linked to neoplasm.