When confront with T2DM‐induced lipotoxicity and glucotoxicity, senescent macrophages secrete proinflammatory cytokines (e.g., TNF‐α) with overproduction of reactive ROS and NO, instigating maladaptive damage/stress responses that heighten diabetes susceptibility in geriatric cohorts [488]. The gene discussed is TNF; the disease is type 2 diabetes mellitus.