IL6 and atherosclerosis: In the early stage of atherosclerosis, senescent T cells contribute to a proinflammatory environment by continuously secreting inflammatory cytokines (e.g., IL‐6 and TNF‐α), exacerbating endothelial injury and pathological vascular remodeling, thereby augmenting risk of atherosclerosis as well as major adverse cardiovascular events [411, 412].