MAPT and Alzheimer disease: The interaction between metabolic dysregulation and immune system activation, particularly microglia and T cells, plays a crucial role in AD pathogenesis by promoting chronic neuroinflammation and further exacerbating the pathological cycle of Aβ accumulation and tau hyperphosphorylation (Hasel et al., 2023; Qiu et al., 2022; Wang et al., 2023; Yin et al., 2016).