Bruedigam et al. also investigated acute myeloid leukaemia (AML) using patient-derived xenograft mouse models (PDX) and found that imetelstat increased lipid peroxidation and increased expression of acyl-CoA synthetase long-chain family member 4 (ACSL4) and fatty acid desaturase 2 (FADS2). This evidence concerns the gene ACSL4 and acute myeloid leukemia.