DKC1 and hereditary disease: DC is a genetic disorder that arises from germline mutations in telomerase components, such as dyskerin/DKC1, which lead to impaired telomerase biogenesis and function, and hence causing telomere shortening during early development and several abnormalities including premature aging and bone marrow failure syndromes (Tummala et al., 2024; Vulliamy et al., 2008).