In Table 5, the Cox multivariate regression analysis exhibited that lymph node metastasis (95% confidence interval [CI]: 1.359–2.909, HR: 1.988, p < 0.001), high UBE2S (95% CI: 1.088–2.560, HR: 1.699, p = 0.019), and FOXM1 (95% CI: 1.244–2.784, HR: 1.861, p = 0.003) expression were risk factors affecting OS of ESCC. This evidence concerns the gene UBE2S and metastatic malignant neoplasm in the lymph nodes.