Our study found that the plasma levels of IL-1β, IL-2, IL-4, IL-10, IL-17, TNF-α, IFN-α, and IFN-γ cytokines in GMG patients who were not treated with drugs were significantly higher than those in healthy controls, and the elevated cytokines reflected the immune activation status of MG. Here, IL4 is linked to myasthenia gravis.