In addition, the TME in HCC mainly includes hepatocytes (ALB+ and KRT18+), endothelial cell (ENG+ and VWF+), B cells (CD79A+ and MS4A1+), Plasma (CD79A+ and JCHAIN+), T cells (CD3D+ and CD3E+), myeloid (CD68+ and FCER1G+), NK cells (NKG7+ and GNLY+), and few fibroblasts (COL1A2+ and RGS5+). The gene discussed is JCHAIN; the disease is hepatocellular carcinoma.