A 11-year-old girl from rural community was referred to the Pediatric Dentistry Clinic, Specialty of Pediatric Dentistry, Dentistry Faculty, previous hematologist had diagnosed symptomatic mild hemophilia A with 46% factor VIII activity and normal von Willebrand factor, the patient was under on-demand treatment, criteria for hemophilia A based on residual factor VIII (FVIII) activity, expressed as a percentage of normal plasma mild > 5% up to < 40%; moderate 1%-5%; severe < 1%. This evidence concerns the gene VWF and hemophilia A.