This case of a 34-year-old female patient, highlights bupropion-associated galactorrhea and hyperprolactinemia, likely due to dopamine receptor downregulation rather than increased dopamine activity. Symptoms resolved rapidly within four days of discontinuing bupropion, with normalization of prolactin levels, supporting a strong causal link. The patient's concurrent sertraline use was deemed unlikely to be the cause, given the typical persistence of SSRI-induced hyperprolactinemia. This evidence concerns the gene PRL and Galactorrhea.