This study looked at 957 women aged 30-44 years with no history of infertility, trying to conceive and found that antidepressant use, particularly SSRIs, was associated with reduced fecundability in women trying to conceive, even after adjusting for a history of depression. The findings suggest the effect may stem from antidepressant-induced suppression of GnRH via increased allopregnanolone, disrupting ovulation without altering cycle length or regularity. This points to a potential medication-specific impact on natural fertility. This evidence concerns the gene GNRH1 and major depressive disorder.