This case highlights the first reported instance of sertraline-induced hyperprolactinemic amenorrhea in a 17-year-old girl, with symptoms resolving after discontinuation of Sertraline. This case analyzes how Sertraline and other SSRIs may elevate prolactin levels by stimulating serotonergic receptors or inhibiting dopaminergic pathways in the hypothalamus. While endocrine side effects are rare, this case underscores the importance of monitoring menstrual changes in adolescents on SSRIs. The gene discussed is PRL; the disease is amenorrhea.