SCD, sudden cardiac death; CHD, coronary heart disease; CVD, cardiovascular disease; cf-PWV, carotid-femoral pulse wave velocity; SBP, systolic blood pressure; DBP, diastolic blood pressure; hsCRP, high-sensitivity C-reactive protein; FMD, flow-mediated dilation; BP, blood pressure; BNP, B-type natriuretic peptide; IHD, ischemic heart disease. The gene discussed is NPPB; the disease is Schnyder corneal dystrophy.