ds-DNA, double-stranded deoxyribonucleic acid; GBM, anti-glomerular basement membrane; p-ANCA, perinuclear anti-neutrophil cytoplasmic antibody; c-ANCA, cytoplasmic antineutrophil cytoplasmic antibody; RA, rheumatoid arthritis; ELISA, Enzyme-Linked Immunosorbent Assay. This evidence concerns the gene PRTN3 and rheumatoid arthritis.