In obesity, particularly with increased visceral fat, adipocytes secrete higher levels of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), while reducing the secretion of the anti-inflammatory adipokine adiponectin, thereby promoting inflammation [4]. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.