PD-L1, programmed death-ligand 1; ICI, immune checkpoint inhibitor; mTOR, mechanistic target of rapamycin; BAP1, BRCA1-associated protein 1; SETD2, SET domain containing 2; HIF-1α, hypoxia-inducible factor 1-alpha; VEGF, vascular endothelial growth factor; uRCC, unclassified renal cell carcinoma. The gene discussed is VEGFA; the disease is Unclassified Renal Cell Carcinoma.