Some unclassified tumors are high-grade malignancies (including those with pure sarcomatoid or rhabdoid morphology and no identifiable epithelial component), whereas others are low-grade neoplasms that simply do not match known benign or malignant renal tumors [12]. In pediatric patients, RCC is rare but shows a different distribution of subtypes; notably, translocation-associated RCC (TFE3 or TFEB rearranged) is more common in children and young adults [13]. The gene discussed is TFEB; the disease is neoplasm.