IVDD: intervertebral disc degeneration; EV: extracellular vesicle; NPC: nucleus pulposus cells; NP: nucleus pulposus; ROS: reactive oxygen species; GLRX3: glutaredoxin 3; ECM: extracellular matrix; ATR: ataxia-telangiectasia and Rad3-related protein; SASP: senescence-associated secretory phenotype; IBU: ibuprofen. This evidence concerns the gene ATR and Intervertebral disk degeneration.