Special staining with Fontana‐Masson highlighted abundant coarse melanin granules within keratinocytes, while Perls’ Prussian blue stain was negative for iron deposition, thereby excluding hemosiderin‐type pigment and minocycline‐related mixed pigmentation (Figure 4). PRAME (preferentially expressed antigen in melanoma) immunohistochemistry was negative. The gene discussed is PRAME; the disease is melanoma.