Multivariate logistic regression analysis further revealed that CREA (OR = 1.002, 95%CI = 1.002–1.003), SOFA (OR = 1.013, 95%CI = 1.006–1.021), APACHE II (OR = 1.009, 95%CI = 1.004–1.014), driving pressure (OR = 1.007, 95%CI = 1.003–1.012), mechanical kinetic energy (OR = 1.006, 95%CI = 1.002–1.010), CRP/ALB (OR = 1.141, 95%CI = 1.068–1.219) and MAP (OR = 0.995, 95%CI = 0.993–0.997) are independent risk factors of SPRMV (p < 0.05) in the elderly patients with AKI, as presented in Table 3. The gene discussed is CRP; the disease is acute kidney injury.