XIAP and myocardial ischemia: By incubating H9C2 cells in a MIRI rat model under hypoxia/reoxygenation (H/R) conditions to simulate myocardial ischemia, exosomal MiR-486-5p played a key role in the regulation process by inhibiting PTEN expression, activating the PI3K/AKT signaling pathway, inducing H9C2 cell proliferation and rescuing H9C2 cell apoptosis (65), LncA2M-AS1 in miR-556-5p improved MIRI-induced cardiomyocyte apoptosis and oxidative stress by regulating the expression of X-linked inhibitor of apoptosis protein (XIAP) (66, 67).