The signaling pathway activates the AKT1/AKT2 signaling pathway, which controls inflammatory cytokines, miRNAs, and functions (including phagocytosis, autophagy, and cellular metabolism) and plays a unique role in macrophage biology and the regulation of inflammatory diseases (84), which can significantly reduce macrophage polarization and alleviate post-infarction inflammatory response in MI rat models (85). The gene discussed is AKT1; the disease is myocardial infarction.