The results showed that human MSC-Exo-derived miR-543 promoted the proliferation, migration, invasion and angiogenesis of cardiac microvascular endothelial cells after MI by downregulating the expression of Collagen Type IV Alpha 1 Chain (COL4A1) (48); the expression level of miR-132 target gene RASp21 protein activator 1 (RASA1) was negatively correlated with the expression of miR-132. This evidence concerns the gene COL4A1 and myocardial infarction.