For EV71, research has delved deeply into specific mechanisms, such as the dual role of the tribbles pseudokinase 3 (TRIB3) pseudokinase in promoting infection, antagonism of interferon signaling pathways, and how capsid protein mutations influence viral entry, alongside advancing antiviral target development, including the monoclonal antibody E1 (70–72). Here, TRIB3 is linked to infection.