F8 and hemophilia: However, according to the World Federation of Hemophilia guidelines for congenital hemophilia, preoperative FVIII levels of 50%–80% are recommended for minor procedures and 80%–100% for major surgeries.15) In the present case, although the FVIII activity remained suboptimal after PE, both the aPTT and ACT improved to levels considered acceptable for proceeding with surgery under careful perioperative hemostatic control.