A previous report of 6 cases with high-titer FVIII inhibitors suggested that PE may not only be effective for temporarily removing FVIII inhibitors but also for facilitating the remission of AHA under adequate immunosuppressive therapy.14) These findings indicate that PE may play a supportive role in the management of AHA, particularly in patients with high-titer FVIII inhibitors who are unresponsive to standard treatments. Here, F8 is linked to autoimmune hemolytic anemia.