INS and Hypoglycemia: The average daily risk range and glycemic instability index showed positive correlations with insulin sensitivity (ρ = 0.5 and ρ = 0.48, respectively; p < 0.01), while hypoglycemia risk metrics demonstrated a negative correlation with maximal epinephrine response during hypoglycemia (ρ = −0.46, p < 0.01) (Pitsillides et al. 2011).