However, the role of CRP in pediatric OSA is nuanced, as other research has noted that CRP in isolation is not predictive of OSA (Kheirandish-Gozal et al., 2015), due to confounding factors such as interindividual variability, environmental, and genetic factors (Kheirandish-Gozal and Gozal, 2017). This evidence concerns the gene CRP and obstructive sleep apnea syndrome.