C9orf72 and amyotrophic lateral sclerosis: Contrary to earlier studies, we did not observe an association of NIPA1 with ALS susceptibility or age at onset.32,45,88,89 The survival association we identified adds to the conflicting literature, highlighting the need for additional replication studies to clarify the role of NIPA1 in (C9orf72-associated) ALS.32,45