While that work focused primarily on intratumoral immune evasion within hepatic lesions, our review aims to extend this understanding by integrating WNT11’s broader mechanistic roles—including its signaling crosstalk with β-catenin, tissue-specific functions in CRC, PDAC, and breast cancers, and immunological influence in liver regeneration niches such as LSECs and Kupffer cells (21). This evidence concerns the gene WNT11 and breast cancer.