In the multivariate Cox regression model, ISPS (HR = 0.645, 95% CI: 0.468–0.889, P = 0.007), TNM stage (HR = 3.305, 95% CI: 2.119–4.121, P < 0.001), tumor size (HR = 1.273, 95% CI: 1.065–1.578, P = 0.012), and CD8+ T cell proportion (HR = 0.903, 95% CI: 0.846–0.974, P = 0.006) were identified as independent prognostic factors for OS (Table 5). Here, CD8A is linked to neoplasm.