Immunohistochemical analysis of the primary tumor in bladder and prostatic showed: Bladder tumor: CK20 (+), 34βE12 (+), p63 (focal+), p53 (+), HER2 (+++), EMA (+), Ki-67 (50%+ in hotspot areas), CK7 (majority+), PSA (−), Vim (−), P40 (−). The gene discussed is ERBB2; the disease is urinary bladder neoplasm.