In contrast, overactivation of multiple angiogenesis- and metastasis-related targets—such as VEGFR1–3, FGFR, PDGFRα, KIT, and RET—is common in iCCA (10) and represents a critical driver of tumorigenesis and progression, making multi-target blockade agents a promising therapeutic approach. Here, RET is linked to infantile convulsions and choreoathetosis.