Due to the complex tumor microenvironment and cellular heterogeneity of iCCA, a series of targets mediating angiogenesis and metastatic invasion—such as VEGFR1-3, FGFR, PDGFRα, KIT, and RET—are excessively activated (10), which are key factors driving tumorigenesis and progression. Here, RET is linked to infantile convulsions and choreoathetosis.