FGF21 and neoplasm: Low expression of FGF21 in PDAC patients is associated with higher TNM stages and increased rates of lymph node metastasis, vascular invasion, and tumor recurrence compared to high expression of FGF21.In vitro and in vivo studies revealed FGF21 significantly suppressed migration and invasion in cultured PDAC cell lines and reduced hepatic metastasis in murine models after LPS treatment.