In patients with the 3-year postoperative follow-up 42 cases (80.77%) in the low expression group had recurrence, while only 10 cases (40.00%) in the high expression group had recurrence, with a significant difference between the two groups (P<0.05), indicating that patients with low expression of FGF21 had a higher tumor recurrence rate. Here, FGF21 is linked to neoplasm.